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1

Chronic Systemic Endotoxin Exposure: An Animal Model in Experimental Hepatic Encephalopathy

Kai O. Lindros, Harri A. Järveläinen

Journal:

Metabolic Brain Disease

Année:

2005

Langue:

english

Fichier:

PDF, 63 KB

english, 2005

2

Allyl Alcohol Liver Injury: Suppression by Ethanol and Relation to Transient Glutathione Depletion

Kai E. Penttilä, Judith Mäkinen, Kai O. Lindros

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1987

Langue:

english

Fichier:

PDF, 497 KB

english, 1987

3

The Effect of Chronic Ethanol Ingestion on Ethanol Metabolizing Enzymes in Isolated Periportal and Perivenous Rat Hepatocytes

Hannu Väänänen, Mikko Salaspuro, Kai Lindros

Journal:

Année:

1984

Langue:

english

Fichier:

PDF, 597 KB

english, 1984

4

Role of ethanol-inducible cytochrome P-450 IIE1 in carbon tetrachloride—induced damage to centrilobular hepatocytes from ethanol-treated rats

Kai O. Lindros, Yuan Cai, Kai E. Penttilä

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 592 KB

english, 1990

5

A rapid method to study heterogeneous gene expression in liver by direct assay of messenger RNA from periportal and perivenous cell lysates

Juhani Saarinen, Ritva Saarelainen, Kai O. Lindros

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 435 KB

english, 1993

6

Zonated expression of cytokines in rat liver: Effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole

Che Fang, Kai O. Lindros, Thomas M. Badger, Martin J.J. Ronis, Prof. Magnus Ingelman-Sundberg

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 246 KB

english, 1998

7

Effect of chronic coadministration of endotoxin and ethanol on rat liver pathology and proinflammatory and anti-inflammatory cytokines

Harri A. Järveläinen, Che Fang, Magnus Ingelman-Sundberg, Kai O. Lindros

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 458 KB

english, 1999

8

Acinar Distribution of Rat Liver Arylamine N-Acetyltransferase: Effect of Chronic Ethanol and Endotoxin Exposure

Pavel S. Pronko, Harri A. Järveläinen, Kai O. Lindros

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

2002

Langue:

english

Fichier:

PDF, 106 KB

english, 2002

9

Functional Differences between Periportal and Perivenous Kupffer Cells Isolated by Digitonin-Collagenase Perfusion

Igor Bykov, Petri Ylipaasto, Leena Eerola, Kai O Lindros

Journal:

Comparative Hepatology

Année:

2004

Langue:

english

Fichier:

PDF, 438 KB

english, 2004

10

The effects of chronic alcohol exposure on the expression of genes encoding superoxide dismutase in muscle

Tatsuo Nakahara, Kijiro Hashimoto, Makoto Hirano, Ross Hunter, Igor Bykov, Kai Lindros, Victor R. Preedy

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 65 KB

english, 2006

11

Does chronic alcohol exposure alter the expression of genes encoding subunits of NADPH oxidase in heart?

Tatsuo Nakahara, Kijiro Hashimoto, Makoto Hirano, Ross Hunter, Igor Bykov, Kai Lindros, Victor R. Preedy

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 73 KB

english, 2006

12

Subcellular Distribution of Human Brain Aldehyde Dehydrogenase

Kazuyoshi Inoue, Kai O. Lindros

Journal:

Journal of Neurochemistry

Année:

1982

Langue:

english

Fichier:

PDF, 390 KB

english, 1982

13

Alcohol-Induced Expression of the CD14 Endotoxin Receptor Protein in Rat Kupffer Cells

Harri A. Järveläinen, Teija Oinonen, Kai O. Lindros

Journal:

Alcoholism: Clinical and Experimental Research

Année:

1997

Langue:

english

Fichier:

PDF, 644 KB

english, 1997

14

CHRONIC ENDOTOXIN/ALCOHOL EXPOSURE: THE DEVELOPMENT OF A NEW ANIMAL MODEL

Kai O. Lindros, Harri Järveläinen, Ari Karjalainen, Heikki Mäkisalo, Pekka J. Karhunen

Journal:

Alcoholism: Clinical and Experimental Research

Année:

1998

Langue:

english

Fichier:

PDF, 263 KB

english, 1998

15

Metronidazole Increases Intracolonic but Not Peripheral Blood Acetaldehyde in Chronic Ethanol-Treated Rats

Jyrki Tillonen, Satu Väkeväinen, Ville Salaspuro, Yong Zhang, Merja Rautio, Hannele Jousimies-Somer, Kai Lindros, Mikko Salaspuro

Journal:

Alcoholism: Clinical and Experimental Research

Année:

2000

Langue:

english

Fichier:

PDF, 86 KB

english, 2000

16

Sex Difference in Alcohol-Related Organ Injury

Nobuhiro Sato, Kai O. Lindros, Enrique Baraona, Kenichi Ikejima, Esteban Mezey, Harri A. Järveläinen, Vijay A. Ramchandani

Journal:

Alcoholism: Clinical and Experimental Research

Année:

2001

Langue:

english

Fichier:

PDF, 63 KB

english, 2001

17

Models of Alcoholic Liver Disease in Rodents: A Critical Evaluation

Pauline de la M. Hall, Charles S. Lieber, Leonore M. DeCarli, Samuel W. French, Kai O. Lindros, Harri Järveläinen, Christiane Bode, Alexandr Parlesak, J. Christian Bode

Journal:

Alcoholism: Clinical and Experimental Research

Année:

2001

Langue:

english

Fichier:

PDF, 821 KB

english, 2001

18

The stimulation of the mitochondrial permeability transition by dihydrolipoate and α-lipoate

Nils-Erik L. Saris, Ari Karjalainen, Vera V. Teplova, Kai O. Lindros

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 407 KB

english, 1998

19

Complement C3 contributes to ethanol‐induced liver steatosis in mice

Bykov, Igor, Junnikkala, Sami, Pekna, Marcela, Lindros, Kai O., Meri, Seppo

Journal:

Annals of Medicine

Année:

2006

Langue:

english

Fichier:

PDF, 471 KB

english, 2006

20

Hepatoprotective mechanism of silymarin: No evidence for involvement of cytochrome P450 2E1

Maria-Prado Miguez, Irene Anundi, Luis A. Sainz-Pardo, Kai O. Lindros

Journal:

Chemico-Biological Interactions

Année:

1994

Langue:

english

Fichier:

PDF, 1.43 MB

english, 1994

21

Brain aldehyde dehydrogenase activity in rat strains with high and low ethanol preferences

Kazuyoshi Inoue, Maija Rusi, Kai O. Lindros

Journal:

Pharmacology Biochemistry and Behavior

Année:

1981

Langue:

english

Fichier:

PDF, 407 KB

english, 1981

22

RP-8 and TRPM-2 gene expression is constitutive in rat liver and increased following galactosamine injury

Mark J. Czaja, Yang Xu, Teija Oinonen, Kai O. Lindros

Journal:

International Hepatology Communications

Année:

1996

Langue:

english

Fichier:

PDF, 1.33 MB

english, 1996

23

Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure

Che Fang, Seokjoo Yoon, Niclas Tindberg, Harri A Järveläinen, Kai O Lindros, Magnus Ingelman-Sundberg

Journal:

Biochemical Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 210 KB

english, 2004

24

Effect of chronic ethanol consumption on the expression of complement components and acute-phase proteins in liver

Igor Bykov, Sami Junnikkala, Marcela Pekna, Kai O. Lindros, Seppo Meri

Journal:

Clinical Immunology

Année:

2007

Langue:

english

Fichier:

PDF, 401 KB

english, 2007

25

Effect of ethanol on the expression of hepatic glutathione S-transferase: an in vivo/in vitro study

Tamara Vanhaecke, Kai O Lindros, Teija Oinonen, Sandra Coecke, Gilda DeBast, Ian R Phillips, Elizabeth A Shephard, Antoine Vercruysse, Vera Rogiers

Journal:

Biochemical Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 388 KB

english, 2000

26

Induction of UDP-glycosyltransferase family 1 genes in rat liver: different patterns of mRNA expression with two inducers, 3-methylcholanthrene and β-naphthoflavone

Sirkku T. Saarikoski, Tarja S. Ikonen, Teija Oinonen, Kai O. Lindros, Ismo Ulmanen, Kirsti Husgafvel-Pursiainen

Journal:

Biochemical Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 1.12 MB

english, 1998

27

No significant expression of CYP2E1 in rat liver stellate cells

Teija Oinonen, Tiina Koivisto, Kai O. Lindros

Journal:

Biochemical Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 355 KB

english, 1998

28

Growth hormone-regulated periportal expression of CYP2C7 in rat liver

Teija Oinonen, Martin Ronis, Tanja Wigell, Katri Tohmo, Thomas Badger, Kai O Lindros

Journal:

Biochemical Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 370 KB

english, 2000

29

Elevated blood acetaldehyde in alcoholics with accelerated ethanol elimination

Kai O. Lindros, Allan Stowell, Pekka Pikkarainen, Mikko Salaspuro

Journal:

Pharmacology Biochemistry and Behavior

Année:

1980

Langue:

english

Fichier:

PDF, 996 KB

english, 1980

30

Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver

Journal:

General Pharmacology: The Vascular System

Année:

1997

Langue:

english

Fichier:

PDF, 683 KB

english, 1997

31

Influence of Thyroid Function on the Acetaldehyde Level of Blood and Liver of Intact Rats during Ethanol Metabolism

Olof A. Forsander, Matti E. Hillbom, Kai O. Lindros

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1969

Langue:

english

Fichier:

PDF, 371 KB

english, 1969

32

Effect of a Low-protein Diet on Acetaldehyde Metabolism in Rats

Kai O. Lindros, Leena Pekkanen, Timo Koivula

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1977

Langue:

english

Fichier:

PDF, 582 KB

english, 1977

33

Biphasic Influence of Dietary Protein Levels on Ethanol-Derived Acetaldehyde Concentrations

Kai O. Lindros, Leena Pekkanen, Timo Koivula

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1978

Langue:

english

Fichier:

PDF, 209 KB

english, 1978

34

Effects of the Dopamine-β-hydroxylase Inhibitors FLA-57 and FLA-63 on Ethanol Metabolism and Aldehyde Dehydrogenase Activity in Rats

Olof Tottmar, Ewa Hellström, Kerstin Holmberg, Kai O. Lindros

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1982

Langue:

english

Fichier:

PDF, 374 KB

english, 1982

35

Role of Selenium-Dependent Glutathione Peroxidase in Protecting against t-Butyl Hydroperoxide-Induced Damage in Hepatocytes

Cai Yuan, Kai E. Penttilä, Georg Alfthan, Kai O. Lindros

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1991

Langue:

english

Fichier:

PDF, 472 KB

english, 1991

36

Regioselective Induction of Liver Glutathione Transferase by Ethanol and Acetone

Helmuth Sippel, Kai E. Penttilä, Kai O. Lindros

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1991

Langue:

english

Fichier:

PDF, 281 KB

english, 1991

37

Evidence for Cytochrome P450 2E1–Mediated Toxicity of N-Nitrosodimethylamine in Cultured Perivenous Hepatocytes from Ethanol Treated Rats

Irene Anundi, Kai O. Lindros

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1992

Langue:

english

Fichier:

PDF, 703 KB

english, 1992

38

Role of the Redox State in Ethanol-Induced Suppression of Citrate-Cycle Flux in the Perfused Liver of Normal, Hyper- and Hypothyroid Rats

Journal:

Année:

1972

Langue:

english

Fichier:

PDF, 888 KB

english, 1972

39

Zonation of cytochrome P450 isozyme expression and induction in rat liver

Rolf BÜHLER, Kai O. LINDROS, Åsa NORDLING, Inger JOHANSSON, Magnus INGELMAN-SUNDBERG

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1992

40

Acetaldehyde Inhibits NF-κB Activation through IκBα Preservation in Rat Kupffer Cells

Kalle Jokelainen, Peter Thomas, Kai Lindros, Amin A. Nanji

Journal:

Biochemical and Biophysical Research Communications

Année:

1998

Langue:

english

Fichier:

PDF, 90 KB

english, 1998

41

Activation of Complement Components and Reduced Regulator Expression in Alcohol-Induced Liver Injury in the Rat

Harri A. Järveläinen, Antti Väkevä, Kai O. Lindros, Seppo Meri

Journal:

Clinical Immunology

Année:

2002

Langue:

english

Fichier:

PDF, 247 KB

english, 2002

42

Effects of ethanol-derived acetaldehyde on the phosphorylation potential and on the intramitochondrial redox state in intact rat liver

Kai O. Lindros, Allan Stowell

Journal:

Archives of Biochemistry and Biophysics

Année:

1982

Langue:

english

Fichier:

PDF, 787 KB

english, 1982

43

2,4-dinitrophenol-induced increase in ethanol and acetaldehyde oxidation in the perfused rat liver

C.J.Peter Eriksson, Kai O. Lindros, Olof A. Forsander

Journal:

Biochemical Pharmacology

Année:

1974

Langue:

english

Fichier:

PDF, 172 KB

english, 1974

44

Effects of long-term ethanol treatment on aldehyde and alcohol dehydrogenase activities in rat liver

Timo Koivula, Kai O. Lindros

Journal:

Biochemical Pharmacology

Année:

1975

Langue:

english

Fichier:

PDF, 583 KB

english, 1975

45

Liver aldehyde and alcohol dehydrogenase activities in rat strains genetically selected for their ethanol preference

Timo Koivula, Martti Koivusalo, Kai O. Lindros

Journal:

Biochemical Pharmacology

Année:

1975

Langue:

english

Fichier:

PDF, 437 KB

english, 1975

46

Breath and blood acetaldehyde concentrations and their correlation during normal and calcium carbimide-modified ethanol oxidation in man

Allan R. Stowell, Kai O. Lindros, Mikko P. Salaspuro

Journal:

Biochemical Pharmacology

Année:

1980

Langue:

english

Fichier:

PDF, 598 KB

english, 1980

47

Alcohol-induced redox changes in the liver of the spontaneously hypertensive rat: Effect of chronic ethanol treatment

Samina Wahid, Jatinder M. Khanna, Frederick J. Carmichael, Kai O. Lindros, Gloria Rachamin, Yedy Israel

Journal:

Biochemical Pharmacology

Année:

1981

Langue:

english

Fichier:

PDF, 712 KB

english, 1981

48

Acinar distribution of glutathione-dependent detoxifying enzymes: Low glutathione peroxidase activity in perivenous hepatocytes

Kera Yoshio, Helmuth W. Sippel, Kai E. Penttilä, Kai O. Lindros

Journal:

Biochemical Pharmacology

Année:

1987

Langue:

english

Fichier:

PDF, 467 KB

english, 1987

49

Drug metabolism by periportal and perivenous rat hepatocytes: Comparison of phase I and phase II reactions and their inducibility during culture

Else-Maj Suolinna, Kai E. Penttilä, Britt-Maj Winell, Ann-Cathrine Sjöholm, Kai O. Lindros‡

Journal:

Biochemical Pharmacology

Année:

1989

Langue:

english

Fichier:

PDF, 750 KB

english, 1989

50

Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studied in isolated periportal and perivenous hepatocytes

Irene Anundi, Tuula Lähteenmäki, Mats Rundgren, Peter Moldeus, Kai O. Lindros

Journal:

Biochemical Pharmacology

Année:

1993

Langue:

english

Fichier:

PDF, 2.04 MB

english, 1993